Head of Medicinal Chemistry

open positions

Job Description

GTN - A Quantum Leap in Drug Discovery.

Bringing a single new drug to the market costs $2.9bn and takes 15 years, with a high chance of failure. At GTN we combine machine learning and quantum physics, using our unique patent-pending technology, Generative Tensorial Networks, to efficiently access the full drug-like space, i.e. 1060, and to more accurately predict chemical activities. This has the potential to create substantial efficiencies in the whole drug development cycle which could have a huge positive impact on lives globally.

GTN is well funded by Tier-1 VCs and has built an outstanding interdisciplinary team, a world-class board of advisors and collaborations with a number of global pharmaceutical companies and world-leading research institutes.

GTN received the CogX UK Rising Star award for Outstanding Achievement in Machine Learning handed to us by the British Prime Minister, Theresa May and was recently featured in WIRED Magazine.

The Role:

GTN currently has an opportunity for a Head of Medicinal Chemistry to join the team within this exciting and growing organisation. You will drive early stage preclinical projects to IND candidates. You will independently lead all aspects of medicinal chemistry on preclinical programs, both internally and within collaborations.

As part of the role you will:

  • Lead medicinal chemistry efforts on preclinical projects from hit identification to IND candidate nomination.
  • Work with external partners to drive synthetic chemistry efforts.
  • Ensure cost-effective solutions are implemented for the execution of medicinal chemistry campaigns and first scale up activities to support discovery programs.
  • Develop external network and relationships with contract research organisations and consultants.
  • Effectively utilise internal tools and capabilities available within GTN to support projects.
  • Ensure molecular modelling and computational support is available for medicinal chemistry programs.
  • interact with colleagues in other areas, such as DMPK, biology, pharmacology and clinical to provide research support required to meet the objective of identifying IND ready compounds.
  • Work with external intellectual property attorneys to provide chemistry and biology information required to support patent filings.
  • You will actively participate in the evaluation and proposal of new project ideas.
  • Evaluate external opportunities as needed within focused therapeutic areas, and ensure competitive intelligence is gathered for ongoing projects.

As part of an ambitious, fast-paced and interdisciplinary team working on tough but impactful challenges, you can expect to work in a collaborative and intellectually fulfilling environment, working on problems that really matter.

Our Values

  • Challenge the norm.
  • Agile, pragmatic perseverance.
  • Approachable and supportive people.
  • Evidenced impact orientation.
  • Personal growth.

What we expect:

  • A PhD in synthetic organic chemistry, or equivalent experience.
  • Highly experienced synthetic and medicinal chemist.
  • Significant experience in small-molecule drug discovery and pre-clinical development.
  • Track record with patents and publications.
  • Significant experience in project planning and management; especially experience in managing timelines and budgets.
  • Experience in working with multi-functional teams and provide a leadership role to ensure individual contributions combine into an effective team effort.
  • Successful track record in working with several target classes such as 7TMs, kinases, proteases, enzymes and PPIs.
  • Sound knowledge in neighbouring disciplines (DMPK, biology, pharmacology, toxicology and safety assesment).
  • Knowledge of molecular modelling and SBDD.
  • Successful multi-tasking team player.
  • Excellent verbal and written communication skills.
  • Innovative thinker.
  • Good judgement and decision-making skills.
  • Ability to interact effectively with the GTN Board, it’s investors and advisors.

  • Ability to travel domestically when required and internationally (not very frequent).
  • Experience in the field of neurodegeneration and oncology.
  • Clear understanding of how contract research organizations operate.
  • Experience of working in inter-company teams, and potentially international teams.
  • Basic understanding of business development.
  • Experience of working in a matrix management organisation.
  • Experience of interacting with an internal SAB and Board members.
  • Interest in expanding network within wider collaborations and building links within internal and external groups.

We offer:

  • Talented, motivated and interesting co-workers.
  • Intellectual challenge solving meaningful problems.
  • Budget to buy the IT set-up you need.
  • Competitive compensation including equity.

Posted: 7th March 2019

Apply now